For the strip below I started with this rough. I had an idea and began to sketch it out panel for panel on graph paper. This was so I could work out angles and placement of the characters. I did this with a ball point pen and just worked with a very sketchy technique. I also tried to work out the placement of word balloons and text.
After I was happy with what I had, I redrew the same thing on larger paper with a technical pencil and after that, inked it with Microns of varying point sizes, paying the most attention to thicker, strong lines. After that i scanned it into Photoshop and colored it. Had a lot of fun trying to select a bright and crisp color palette.